Molecular contributions to neurovascular unit dysfunctions after brain injuries: lessons for target-specific drug development

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Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery

The blood-brain barrier (BBB) is a dynamic and highly selective permeable interface between central nervous system (CNS) and periphery that regulates the brain homeostasis. Increasing evidences of neurological disorders and restricted drug delivery process in brain make BBB as special target for further study. At present, neurovascular unit (NVU) is a great interest and highlighted topic of pha...

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Radiotherapy is commonly used in the treatment of pediatric brain tumors but is unfortunately associated with debilitating negative effects, such as impaired memory and learning. Historically, vascular damage following radiotherapy was considered the primary injury which in turn caused ischemia and necrosis. This hypothesis was supported by studies reporting structural changes to blood vessels,...

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In the ischemic brain, reperfusion with tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT); however, the mechanism remains elusive. Here, we show that the basement membrane, and not the endothelial cells, is vulnerable to ischemic/reperfusion injury with tPA treatment. We treated a spontaneously hypertensive rat model of middle cerebral artery occlu...

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ژورنال

عنوان ژورنال: Future Neurology

سال: 2013

ISSN: 1479-6708,1748-6971

DOI: 10.2217/fnl.13.55